Curcumae radix Reduces Endoplasmic Reticulum Stress in Mice with Chronic Neuroinflammation

Endoplasmic reticulum (ER) stress is a condition in which the ER protein-folding machinery impaired, leading to accumulation of improperly folded proteins and triggering an unfolded-protein response. Excessive causes cell death contributes development chronic diseases. Interestingly, there bidirectional relationship between nuclear factor-kappa B (NF-κB) pathway. Curcumin, natural polyphenolic compound found Curcumae radix, exerts its neuroprotective effects by regulating inflammation. Therefore, investigating potential protective regulatory curcumin on stress, inflammation, neurodegeneration under neuroinflammatory conditions great interest. Mice were pretreated with radix extract (CRE) for 19 days then treated CRE plus lipopolysaccharide 1 week. We monitored pro-inflammatory cytokine levels serum stress-, inflammation-, neurodegeneration-related markers mouse cerebrum hippocampus using Western blotting qRT-PCR. reduced Interleukin-1 beta blood brain mice lipopolysaccharide-induced also suppressed expression related NF-κB signaling pathways. The was hippocampus. inflammatory via multifaceted anti-inflammatory stress-pathway mechanisms.